The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Apr. 08, 2011
Applicants:

Stephen C. Harrison, Brighton, MA (US);

Bing Chen, Westwood, MA (US);

Dan C. Barouch, Brookline, MA (US);

Joseph P. Nkolola, Watertown, MA (US);

Michael Scott Seaman, West Roxbury, MA (US);

Inventors:

Stephen C. Harrison, Brighton, MA (US);

Bing Chen, Westwood, MA (US);

Dan C. Barouch, Brookline, MA (US);

Joseph P. Nkolola, Watertown, MA (US);

Michael Scott Seaman, West Roxbury, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C12Q 1/68 (2006.01); C07H 21/04 (2006.01); C07K 14/005 (2006.01); A61K 39/21 (2006.01); A61K 39/12 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); A61K 2039/53 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/575 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01);
Abstract

Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.


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