The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Dec. 04, 2013
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Washington, DC (US);
Stephen S. Whitehead, Bethesda, MD (US);
Brian R. Murphy, Bethesda, MD (US);
Kathryn A. Hanley, Las Cruces, NM (US);
Joseph E. Blaney, Gettysburg, PA (US);
Ching-Juh Lai, Bethesda, MA (US);
Abstract
The invention features novel attenuated dengue virus mutants and compositions thereof. The invention further features an attenuated dengue virus comprising a proline to leucine change at amino acid position 2343 of non-structural protein 4B (NS4B), wherein the numbering is based upon the prototypic isolate DEN4 Dominica 1981 and the attenuated mutant DEN virus has at least one of the following properties: improved replication in Vero cells or restricted replication in mosquito cells.