The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Feb. 18, 2010
Applicants:

David Bar-or, Englewood, CO (US);

Raphael Bar-or, Denver, CO (US);

Richard Shimonkevitz, Highlands Ranch, CO (US);

Inventors:

David Bar-Or, Englewood, CO (US);

Raphael Bar-Or, Denver, CO (US);

Richard Shimonkevitz, Highlands Ranch, CO (US);

Assignee:

Ampio Pharmaceuticals, Inc., Englewood, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 43/00 (2006.01); A61K 38/12 (2006.01); A61K 31/495 (2006.01); A61K 45/06 (2006.01); C07D 241/08 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/495 (2013.01); A61K 9/00 (2013.01); A61K 9/0048 (2013.01); A61K 38/12 (2013.01); A61K 45/06 (2013.01); C07D 241/08 (2013.01);
Abstract

The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.


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