The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Oct. 31, 2012
Applicant:

Avedro, Inc., Waltham, MA (US);

Inventors:

Marc D. Friedman, Needham, MA (US);

Pavel Kamaev, Lexington, MA (US);

Evan Sherr, Ashland, MA (US);

William Eddington, Cambridge, MA (US);

Sara Rood-Ojalvo, Boston, MA (US);

David Muller, Boston, MA (US);

Assignee:

Avedro, Inc., Waltham, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61M 37/00 (2006.01); A61F 9/00 (2006.01); A61F 9/007 (2006.01); A61N 5/06 (2006.01); A61K 41/00 (2006.01); A61K 31/525 (2006.01); A61F 9/013 (2006.01); A61F 9/008 (2006.01);
U.S. Cl.
CPC ...
A61F 9/0008 (2013.01); A61F 9/0079 (2013.01); A61K 31/525 (2013.01); A61K 41/00 (2013.01); A61N 5/062 (2013.01); A61F 9/013 (2013.01); A61F 2009/00872 (2013.01);
Abstract

A method for controlling activation of Riboflavin applied to an eye includes applying the Riboflavin to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the Riboflavin with pulsed light illumination. The pulsed light illumination has an irradiance, dose, and an on/off duty cycle. The irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for Riboflavin cross-linking activity and to control photochemical efficiency.


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