The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2017
Filed:
Aug. 12, 2013
Applicant:
Uvic Industry Partnerships Inc., Victoria, CA;
Inventors:
Reuven Gordon, Victoria, CA;
Yuanjie Pang, Ann Arbor, MI (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/01 (2006.01); G01N 33/566 (2006.01); G01N 21/35 (2014.01); G01N 21/64 (2006.01); G01N 21/65 (2006.01);
U.S. Cl.
CPC ...
G01N 33/566 (2013.01); G01N 21/35 (2013.01); G01N 21/64 (2013.01); G01N 21/65 (2013.01);
Abstract
Molecules or particle having a hydrodynamic radius as small as 3.5 nm can be trapped using a double-nanohole structure defined in a metal film or other metallic layer. Application of a suitable optical radiation flux to the double-nanohole structure can provide a folding and/or binding of protein molecules that can be identified based on changes in optical transmission. Varying nanohole transmissions can thus be associated with trapping, binding and unfolding of biological particles. The double-nanohole defines cusps, but such cusps can be defined in other ways as well.