The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2017
Filed:
Jan. 24, 2014
Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
Jenkem Technology Co. Ltd., Tianjin Branch, Tianjin, CN;
Jinliang Wang, Tianjin, CN;
Xuan Zhao, Tianjin, CN;
Zhenguo Wang, Tianjin, CN;
Zewang Feng, Tianjin, CN;
Jianhuan Jia, Tianjin, CN;
JENKEM TECHNOLOGY CO., LTD., TIANJIN BRANCH, Teda Development Zone, Tianjin, CN;
Abstract
A conjugate of water soluble polymer-amino acid oligopeptide-drug of Formula (I) below and a pharmaceutical composition comprising the conjugate are provided. In the conjugate, P is a water soluble polymer; X is a linking group, wherein the linking group links P and A; each of A, Aand Ais independently same or different amino acid residue or amino acid analogue residue; each of Dand Dis independently same or different drug molecule residue; a is 0 or 1; b is an integer of 2-12; c is an integer of 0-7; d is 0 or 1. The conjugate could improve drug load capacity, water solubility, stability and activity of the drug.