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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9700611 B1

PDFFull Text
Date of Patent:
Jul. 11, 2017

Filed:

Jun. 02, 2016

Live attenuated catfish vaccine and method of making

Applicant:

Mississippi State University, Mississippi State, MS (US);

Inventors:

Mark L. Lawrence, Starkville, MS (US);

Attila Karsi, Starkville, MS (US);

Assignee:

MISSISSIPPI STATE UNIVERSITY, Starkville, MS (US);

Attorney:

Butler Snow LLP

Primary Examiner:

Brian J Gangle

Int. Cl.
CPC ...
A61K 39/02 (2006.01); C12N 1/20 (2006.01); C12N 1/36 (2006.01); C12N 9/02 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 9/06 (2006.01); C12N 15/10 (2006.01); C12Q 1/02 (2006.01); C12Q 1/66 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/025 (2013.01); C12N 1/20 (2013.01); C12N 1/36 (2013.01); C12N 9/001 (2013.01); C12N 9/0006 (2013.01); C12N 9/0014 (2013.01); C12N 9/0051 (2013.01); C12N 9/1014 (2013.01); C12N 15/102 (2013.01); C12Q 1/025 (2013.01); C12Q 1/66 (2013.01); C12Y 101/01037 (2013.01); C12Y 103/00 (2013.01); C12Y 103/05001 (2013.01); C12Y 104/04002 (2013.01); C12Y 108/01004 (2013.01); C12Y 201/0201 (2013.01); A61K 2039/522 (2013.01); A61K 2039/552 (2013.01);
Abstract

Live attenuated bacteria vaccines against enteric septicemia of fish, especially catfish, and methods related to the same. Mutant strains of the bacteria(a pathogenic bacterial strain of) are provided. The mutantbacteria (or other pathogenic bacterial strain of) contain one or more gene deletions or disruptions that result in less virulent bacterial strains as live attenuated vaccine compositions against virulent wild-typebacteria (or other pathogenic bacterial strain of). The mutant strains showing the best immunological protection and safety as a vaccine are the triple mutants ESC-NDKL1 (ΔgcvPΔsdhCΔfrdA) strain and ESC-NDKL2 (ΔgcvPΔsdhCΔmdh) strain, with the ESC-NDKL1 strain providing the greatest safety and efficacy of these two triple mutants.

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