The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 11, 2017

Filed:

Jun. 04, 2015
Applicants:

University of South Florida, Tampa, FL (US);

H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);

Inventors:

Huntington Potter, Denver, CO (US);

Timothy Boyd, Aurora, CO (US);

Heather Sevey Lawrence Jim, Tampa, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A01N 37/18 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 38/18 (2006.01); A01K 67/027 (2006.01); C07K 14/535 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/193 (2013.01); A01K 67/0275 (2013.01); A61K 38/1709 (2013.01); A61K 38/1816 (2013.01); C07K 14/535 (2013.01); A01K 2207/30 (2013.01); A01K 2217/052 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0312 (2013.01); A01K 2267/0356 (2013.01); A61K 48/005 (2013.01);
Abstract

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.


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