The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Feb. 19, 2016
Applicant:
Molecular Assemblies, Inc., San Diego, CA (US);
Inventors:
J. William Efcavitch, San Carlos, CA (US);
Suhaib Siddiqi, Burlington, MA (US);
Assignee:
Molecular Assemblies, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6844 (2013.01); C12P 19/34 (2013.01); C12Q 1/6806 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00722 (2013.01); Y02P 20/582 (2015.11);
Abstract
The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3' OH, i.e., as found in 'natural' deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.