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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9695454 B1

PDFFull Text
Date of Patent:
Jul. 04, 2017

Filed:

May. 23, 2013

Production of fucosylated glycoproteins

Applicants:

Glykos Finland Oy, Helsinki, FI;

Novartis Ag, Basel, CH;

Inventors:

Jari Natunen, Vantaa, FI;

Ann Westerholm-Parvinen, Kirkkonummi, FI;

Hanna Salo, Helsinki, FI;

Jussi Joensuu, Tervakoski, FI;

Heli Viskari, Nummela, FI;

Christopher Landowski, Helsinki, FI;

Anne Huuskonen, Helsinki, FI;

Anne Kanerva, Helsinki, FI;

Anna-Liisa Hanninen, Helsinki, FI;

Noora Salovuori, Helsinki, FI;

Merja Penttila, Helsinki, FI;

Juhani Saarinen, Helsinki, FI;

Markku Saloheimo, Helsinki, FI;

Assignee:

GLYKOS FINLAND OY, Helsinki, FI;

Attorney:

Patrick J. Halloran

Primary Examiner:

Karen Cochrane Carlson

Int. Cl.
CPC ...
C12R 1/885 (2006.01); C12P 21/00 (2006.01); C07K 14/435 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 9/58 (2006.01); C12N 9/88 (2006.01); C12N 15/52 (2006.01); C07K 16/00 (2006.01); C12N 15/80 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 14/43545 (2013.01); C07K 16/00 (2013.01); C12N 9/0006 (2013.01); C12N 9/1051 (2013.01); C12N 9/58 (2013.01); C12N 9/88 (2013.01); C12N 15/52 (2013.01); C12N 15/80 (2013.01); C07K 2319/01 (2013.01);
Abstract

Described herein are compositions including filamentous fungal cells, such asfungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example,fungal cells, as the expression system.

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