The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
May. 24, 2013
Applicant:
Commissariat a I'energie Atomique ET Aux Energies Alternatives, Paris, FR;
Inventor:
Nicole Deglon, Marseille, CH;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C12N 15/111 (2013.01); C12N 2330/51 (2013.01); C12N 2740/15033 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/15045 (2013.01); C12N 2740/16033 (2013.01); C12N 2740/16043 (2013.01); C12N 2810/6081 (2013.01); C12N 2830/003 (2013.01); C12N 2830/205 (2013.01); C12N 2830/48 (2013.01);
Abstract
The present invention relates to a viral vector for silencing a gene specifically in astrocytes comprising: —an astrocyte-specific viral envelope protein, —a first nucleic acid sequence encoding a transcription activator and at least one target sequence of a neuron-specific miR under the control of an astrocyte-specific promoter, and—a second nucleic acid sequence encoding a RNA for silencing the gene under the control of a promoter inducible by the transcription activator.