The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Sep. 03, 2015
Applicant:
Gradalis, Inc., Dallas, TX (US);
Inventors:
John J. Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Delray Beach, FL (US);
Phillip B. Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
Assignee:
GRADALIS, INC., Dallas, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); C12N 15/113 (2010.01); A61K 38/21 (2006.01); C12N 15/85 (2006.01); C07K 14/535 (2006.01); A61K 38/19 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 38/193 (2013.01); A61K 38/217 (2013.01); A61K 48/005 (2013.01); C07K 14/535 (2013.01); C12N 15/85 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2320/35 (2013.01); C12N 2330/51 (2013.01); C12N 2830/20 (2013.01); C12N 2840/107 (2013.01);
Abstract
Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.