The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Jun. 21, 2012
Jan Steyaert, Beersel, BE;
Els Pardon, Lubbeek, BE;
Toon Laeremans, Dworp, BE;
Brian Kobilka, Palo Alto, CA (US);
Søren Rasmussen, Frederiksberg, DK;
Sebastian Granier, Menlo Park, CA (US);
Roger K. Sunahara, Ann Arbor, MI (US);
Jan Steyaert, Beersel, BE;
Els Pardon, Lubbeek, BE;
Toon Laeremans, Dworp, BE;
Brian Kobilka, Palo Alto, CA (US);
Søren Rasmussen, Frederiksberg, DK;
Sebastian Granier, Menlo Park, CA (US);
Roger K. Sunahara, Ann Arbor, MI (US);
Vrije Universiteit Brussel, Brussels, BE;
VIB VZW, Ghent, BE;
The Board of Trustees of the Leland Stanford Junior Universitv, Palo Alto, CA (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.