The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Dec. 28, 2015
Nitto Denko Corporation, Osaka, JP;
Kenjirou Minomi, Osaka, JP;
Jens Harborth, Carlsbad, CA (US);
Cima Cina, San Diego, CA (US);
Kwok Yin Tsang, Irvine, CA (US);
Wenbin Ying, San Diego, CA (US);
Hirokazu Takahashi, Osaka, JP;
Nitto Denko Corporation, Osaka, JP;
Abstract
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.