IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9695195 B1

PDFFull Text
Date of Patent:
Jul. 04, 2017

Filed:

Mar. 08, 2016

5-ht3 receptor antagonists

Applicant:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

Stephen Hitchcock, San Diego, CA (US);

Holger Monenschein, San Diego, CA (US);

Holly Reichard, San Diego, CA (US);

Huikai Sun, San Diego, CA (US);

Shota Kikuchi, San Diego, CA (US);

Todd Macklin, San Diego, CA (US);

Maria Hopkins, San Diego, CA (US);

Assignee:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Attorneys:

Matthew J. Russo

David M. Stemerick

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 519/00 (2006.01); C07D 498/04 (2006.01); A61K 31/537 (2006.01); C07D 498/08 (2006.01); C07D 451/12 (2006.01); A61K 31/19 (2006.01); A61K 31/5386 (2006.01); C07D 221/22 (2006.01); C07C 53/40 (2006.01); C07D 453/02 (2006.01); C07D 471/08 (2006.01); C07C 53/18 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); A61K 31/19 (2013.01); A61K 31/5386 (2013.01); C07C 53/18 (2013.01); C07C 53/40 (2013.01); C07D 221/22 (2013.01); C07D 451/12 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides compounds of the formula: that are 5HT3 receptor antagonists and are therefore useful for the treatment of diseases treatable by inhibition of 5HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

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