The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Jul. 01, 2014
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Matthew O. Duffey, Chicago, IL (US);
Dylan B. England, Milford, MA (US);
Zhigen Hu, Somerville, MA (US);
Mitsuhiro Ito, Kanagawa, JP;
Steven P. Langston, North Andover, MA (US);
Charles McIntyre, Cambridge, MA (US);
Hirotake Mizutani, Cambridge, MA (US);
He Xu, Needham, MA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, R, R, R, R, X, R, R, R, R, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.