The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Jan. 21, 2014
New York University, New York, NY (US);
The Ohio State University Research Foundation, Columbus, OH (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Paramjit S. Arora, Cold Spring Harbor, NY (US);
Quintin Pan, Dublin, OH (US);
Anna Mapp, Ann Arbor, MI (US);
New York University, New York, NY (US);
The Ohio State University Research Foundation, Columbus, OH (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R, R, R, R, and B are as defined herein).