The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Sep. 07, 2012
Ivan Alferiev, Clementon, NJ (US);
Ilia Fishbein, Philadelphia, PA (US);
Michael Chorny, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
Benjamin Yellen, Durham, NC (US);
Darryl Williams, Philadelphia, PA (US);
Ivan Alferiev, Clementon, NJ (US);
Ilia Fishbein, Philadelphia, PA (US);
Michael Chorny, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
Benjamin Yellen, Durham, NC (US);
Darryl Williams, Philadelphia, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Abstract
A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.