The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2017
Filed:
Oct. 07, 2015
Applicant:
Mallinckrodt Pharma Ip Trading D.a.c., Dublin, IE;
Inventors:
Assignee:
Mallinckrodt Oharma IP Trading D.A.C., Dublin, IE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/56 (2006.01); C12P 21/04 (2006.01); A61K 38/00 (2006.01); C07K 14/75 (2006.01); A61K 38/36 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/363 (2013.01); C12P 21/005 (2013.01);
Abstract
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of α-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by α-extended fibrinogen are improved. In addition, plasmin-mediated degradation of α-extended fibrinogen is reduced as compared to plasma derived fibrinogen.