The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 04, 2017

Filed:

Nov. 05, 2015
Applicants:

University of Rochester, Rochester, NY (US);

Board of Regents of the University of Nebraska, Lincoln, NE (US);

Temple University—of the Commonwealth System of Higher Education, Philadelphia, PA (US);

Inventors:

Paul M. Dunman, Pittsford, NY (US);

Patrick D. Olson, St. Louis, MO (US);

Wayne Childers, New Hope, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/402 (2006.01); C07D 207/337 (2006.01); A61K 31/427 (2006.01); C07D 307/68 (2006.01); C07D 307/56 (2006.01); C07D 405/06 (2006.01); C07D 417/06 (2006.01); A61K 31/341 (2006.01); A61K 45/06 (2006.01); C12Q 1/44 (2006.01);
U.S. Cl.
CPC ...
A61K 31/427 (2013.01); A61K 31/341 (2013.01); A61K 31/402 (2013.01); A61K 45/06 (2013.01); C07D 207/337 (2013.01); C07D 307/56 (2013.01); C07D 307/68 (2013.01); C07D 405/06 (2013.01); C07D 417/06 (2013.01); C12Q 1/44 (2013.01); G01N 2333/922 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract

Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.


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