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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9693988 B1

PDFFull Text
Date of Patent:
Jul. 04, 2017

Filed:

Sep. 13, 2012

Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent

Applicants:

Yunik Chang, Sonoma, CA (US);

Gordon J. Dow, Santa Rosa, CA (US);

Inventors:

Yunik Chang, Sonoma, CA (US);

Gordon J. Dow, Santa Rosa, CA (US);

Assignee:

DOW PHARMACEUTICAL SCIENCES, INC., Petaluma, CA (US);

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

William Lee

Int. Cl.
CPC ...
A61K 31/327 (2006.01); A61K 9/00 (2006.01); A61K 31/075 (2006.01); A61K 47/10 (2017.01); A61K 31/7056 (2006.01); A61K 8/38 (2006.01); A61K 45/06 (2006.01); A61Q 19/00 (2006.01); A61K 31/235 (2006.01); A61K 9/14 (2006.01); A61K 47/32 (2006.01); A61K 8/02 (2006.01); A61K 8/04 (2006.01); A61K 8/34 (2006.01); A61K 8/55 (2006.01);
U.S. Cl.
CPC ...
A61K 31/327 (2013.01); A61K 8/0241 (2013.01); A61K 8/042 (2013.01); A61K 8/044 (2013.01); A61K 8/345 (2013.01); A61K 8/38 (2013.01); A61K 8/55 (2013.01); A61K 9/0014 (2013.01); A61K 9/14 (2013.01); A61K 31/075 (2013.01); A61K 31/235 (2013.01); A61K 31/7056 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/32 (2013.01); A61Q 19/00 (2013.01); A61K 2800/33 (2013.01); A61K 2800/413 (2013.01);
Abstract

An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following, application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

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