The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Aug. 13, 2016
Vib Vzw, Gent, BE;
Vrije Universiteit Brussel, Brussels, BE;
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Jan Steyaert, Beersel, BE;
Juan Jose Fung, San Jose, CA (US);
Brian Kobilka, Palo Alto, CA (US);
Toon Laeremans, Dworp, BE;
Els Pardon, Lubbeek, BE;
Soren G. F. Rasmussen, Palo Alto, CA (US);
VIB VZW, Ghent, BE;
Vrije Universiteit Brussel, Brussels, BE;
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.