The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2017

Filed:

Aug. 27, 2014
Applicant:

Pacific Biosciences of California, Inc., Menlo Park, CA (US);

Inventors:

Denis Zaccarin, San Jose, CA (US);

Stephen Turner, Seattle, WA (US);

Pezhman Monadgemi, Fremont, CA (US);

Ravi Saxena, San Francisco, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 (2006.01); G01N 21/64 (2006.01); G01N 21/25 (2006.01); G02B 6/13 (2006.01); G02B 6/136 (2006.01); B05D 1/00 (2006.01); C23C 16/50 (2006.01); G02B 6/12 (2006.01); G02B 6/132 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6452 (2013.01); B05D 1/005 (2013.01); C23C 16/50 (2013.01); G01N 21/253 (2013.01); G02B 6/12002 (2013.01); G02B 6/131 (2013.01); G02B 6/132 (2013.01); G02B 6/136 (2013.01); G02B 2006/12035 (2013.01); G02B 2006/12061 (2013.01); G02B 2006/12104 (2013.01); G02B 2006/12164 (2013.01); G02B 2006/12197 (2013.01);
Abstract

Processes for making high multiplex arrays for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. The high multiplex arrays include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.


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