The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Feb. 06, 2013
Ajou University Industry-academic Cooperation Foundation, Suwon-si, Gyeonggi-do, KR;
Woo Young Shim, Suwon-si, KR;
Duc Toan Nguyen, Hanoi, VE;
Gwang Lee, Suwon-si, KR;
Man Jeong Paik, Seoul, KR;
Jae Ho Kim, Seongnam-si, KR;
Sang Mi Hyun, Seoul, KR;
Ki Ryung Choi, Seoul, KR;
Sung Su Park, Seoul, KR;
Jin Seok Kang, Seongnam-si, KR;
Jeom Soon Shim, Seoul, KR;
Tae-Hwan Shin, Daegu, KR;
Geetika Phukan, Suwon-si, KR;
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Suwon-si, Gyeonggi-Do, KR;
Abstract
Disclosed is a biomarker composition for diagnosing the toxicity of nanoparticles, which shows a change in expression by exposure to the nanoparticles, the biomarker composition comprising at least one gene selected from the group consisting of aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamicoxaloacetic transaminase, glutamic acid decarboxylase and glutamate-ammonia ligase, and to a method for evaluating the toxicity of nanoparticles using the same. The biomarker is a gene marker having a high correlation with the toxicity of nanoparticles, and the use of the biomarker can determine whether nanoparticles have toxicity, with high detection sensitivity. Also, the method is useful in monitoring or evaluating the toxicity of nanoparticles by analyzing factors having a high correlation with toxicity of nanoparticles. Furthermore, the method can be effectively used as a tool for studying various diseases caused by exposure to nanoparticles or evaluating the effects of nanoparticles on health.