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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9688992 B1

PDFFull Text
Date of Patent:
Jun. 27, 2017

Filed:

Nov. 29, 2012

Inhibitory oligonucleotide and use thereof

Applicant:

Sbi Biotech Co., Ltd., Tokyo, JP;

Inventors:

Eiji Esashi, Tokyo, JP;

Liying Wang, Changchun, CN;

Yongli Yu, Changchun, CN;

Assignee:

SBI Biotech Co., Ltd., Tokyo, JP;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Jane Zara

Int. Cl.
CPC ...
C12N 15/117 (2010.01); A61P 37/02 (2006.01); A61P 37/06 (2006.01); A61K 31/711 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C12N 15/117 (2013.01); A61K 31/711 (2013.01); A61K 47/48215 (2013.01); C12N 2310/17 (2013.01); C12N 2310/315 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01);
Abstract

The inhibitory oligonucleotides (ODNs) which strongly block NF-κB activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, is inhibited by the inhibitory-ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory-ODNs. These ODNs can be used as a remedy for the treatment of immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes.

Find Patent Forward Citations

Esashi, Eiji. (2017). Inhibitory oligonucleotide and use thereof (U.S. Patent No. 9688992). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9688992

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