The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2017

Filed:

Nov. 03, 2011
Applicants:

Anna Hultberg, Sint-Martens-Latem, BE;

Michael Saunders, Brussels, BE;

Johannes DE Haard, Oudelande, BE;

Els Festjens, Zwevegem, BE;

Natalie DE Jonge, Aalst, BE;

Paolo Michieli, Rivalta di Torina, IT;

Cristina Basilico, Pavarolo, IT;

Torsten Dreier, Sint-Martems Latem, BE;

Inventors:

Anna Hultberg, Sint-Martens-Latem, BE;

Michael Saunders, Brussels, BE;

Johannes De Haard, Oudelande, BE;

Els Festjens, Zwevegem, BE;

Natalie De Jonge, Aalst, BE;

Paolo Michieli, Rivalta di Torina, IT;

Cristina Basilico, Pavarolo, IT;

Torsten Dreier, Sint-Martems Latem, BE;

Assignee:

ARGEN-X N.V., Breda, NL;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); C07K 16/2863 (2013.01); A61K 2039/505 (2013.01); C07K 2317/14 (2013.01); C07K 2317/22 (2013.01); C07K 2317/30 (2013.01); C07K 2317/33 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

The invention provides a product combination or composition, and also multispecific antibodies comprising two or more antigen-binding sites (as antibodies or antigen binding fragments thereof), wherein two the antigen-binding bind to distinct non-overlapping epitopes of the human c-Met protein. The product combination or composition or multispecific antibody inhibits HGF-independent activation of the human c-Met receptor protein.


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