The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Oct. 28, 2013
Applicants:
Deutsches Rheuma-forschungszentrum Berlin, Berlin, DE;
Engelhardt Institute of Molecular Biology, Moscow, RU;
Inventors:
Sergei Nedospasov, Berlin, DE;
Andrey Kruglov, Berlin, DE;
Grigory Alexandrovich Efimov, Moscow, RU;
Assignee:
DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN, Berlin, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); C12N 15/13 (2006.01); C07K 16/46 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); C07K 16/241 (2013.01); C07K 16/2803 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01);
Abstract
The invention relates to isolated bispecific affinity reagents, such as antibodies or antibody fragments that bind TNFα and a marker molecule for macrophages and/or neutrophils. The affinity reagents of the invention enable pathogenic sub-populations of TNFα to be neutralized, while protective sub-populations of TNFα are not affected.