The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Dec. 17, 2012
Amgen Inc., Thousand Oaks, CA (US);
Jeonghoon Sun, San Diego, CA (US);
Seog Joon Han, Simi Valley, CA (US);
Susie M Harris, Newbury Park, CA (US);
Randal R Ketchem, Snohomish, WA (US);
Ji Lu, Thousand Oaks, CA (US);
Mark L Michaels, Encino, CA (US);
Marc W Retter, Simi Valley, CA (US);
Mei-Mei Tsai, Thousand Oaks, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides.