The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Nov. 02, 2011
Luigi Aurisicchio, Rome, IT;
Gennaro Ciliberto, Rome, IT;
Rita Mancini, Rome, IT;
Emanuele Marra, Pomezia, IT;
Guiseppe Roscilli, Rome, IT;
Luigi Aurisicchio, Rome, IT;
Gennaro Ciliberto, Rome, IT;
Rita Mancini, Rome, IT;
Emanuele Marra, Pomezia, IT;
Guiseppe Roscilli, Rome, IT;
TAKIS S.R.L., Rome, IT;
Abstract
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and/or genetic vectors carrying a codon-usage optimized sequence and coding for a mutant form of the ErbB-3 receptor. Furthermore, the invention refers to monoclonal antibodies directed against the ErbB-3 receptor, obtained using these methods and capable to block its activity in cancer cells.