The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2017

Filed:

Mar. 08, 2012
Applicants:

Caius G. Radu, Los Angeles, CA (US);

Hsiang-i Liao, Arcadia, CA (US);

Nagichettiar Satyamurthy, Los Angeles, CA (US);

Johannes Czernin, Pacific Palisades, CA (US);

Jennifer M. Murphy, Los Angeles, CA (US);

David A. Nathanson, Los Angeles, CA (US);

Inventors:

Caius G. Radu, Los Angeles, CA (US);

Hsiang-I Liao, Arcadia, CA (US);

Nagichettiar Satyamurthy, Los Angeles, CA (US);

Johannes Czernin, Pacific Palisades, CA (US);

Jennifer M. Murphy, Los Angeles, CA (US);

David A. Nathanson, Los Angeles, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); C07D 417/14 (2013.01); G01N 33/5088 (2013.01);
Abstract

The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.


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