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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9688662 B1

PDFFull Text
Date of Patent:
Jun. 27, 2017

Filed:

Mar. 31, 2014

N-(2,3-dihydro-1h-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and n-(2,3-dihydro-1h-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Ian Stansfield, Val de Reuil, FR;

Yannick Aime Eddy Ligny, Val de Reuil, FR;

Nathalie Claudie Isabelle Amblard, Val de Reuil, FR;

Matthias Luc Aime Versele, Val de Reuil, FR;

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:
Primary Examiner:

Kamal Saeed

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/4045 (2006.01); A61K 31/407 (2006.01); A61K 31/517 (2006.01); C07D 239/72 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 31/407 (2013.01); A61K 31/4045 (2013.01); A61K 31/517 (2013.01); C07D 239/72 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 491/056 (2013.01);
Abstract

The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R, R, R, R, R, Rand A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

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