The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2017

Filed:

Jul. 24, 2013
Applicant:

Nerviano Medical Sciences S.r.l., Nerviano (MI), IT;

Inventors:

Maria Gabriella Brasca, Nerviano, IT;

Simona Bindi, Milan, IT;

Marina Caldarelli, Milan, IT;

Marcella Nesi, Saronno, IT;

Sten Christian Orrenius, Nerviano, IT;

Achille Panzeri, Merate, IT;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 401/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/53 (2006.01); A61K 31/506 (2006.01); A61K 31/437 (2006.01); C07D 473/00 (2006.01); A61K 45/06 (2006.01); C07F 5/04 (2006.01); C07F 7/08 (2006.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/53 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 473/00 (2013.01); C07D 487/04 (2013.01); C07F 5/04 (2013.01); C07F 7/083 (2013.01);
Abstract

The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.


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