The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Aug. 13, 2014
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
I-Wei Chen, Swarthmore, PA (US);
Hoon Choi, Newtown Square, PA (US);
Rong Zhou, Cherry Hill, NJ (US);
Assignee:
The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 9/51 (2006.01); C12N 15/11 (2006.01); A61K 31/337 (2006.01); A61K 31/416 (2006.01); A61K 31/433 (2006.01); C07K 7/08 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/48884 (2013.01); A61K 9/5169 (2013.01); A61K 31/337 (2013.01); A61K 31/416 (2013.01); A61K 31/433 (2013.01); A61K 47/48215 (2013.01); A61K 47/48315 (2013.01); A61K 47/48807 (2013.01); A61K 47/48907 (2013.01); C07K 7/08 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3513 (2013.01); C12N 2320/32 (2013.01); C12N 2320/51 (2013.01);
Abstract
A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as near a tumor site (pH˜6.5-6.9), the peptides may dissolve, releasing the biological substance. Also provided are the delivery methods and related kits.