The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Jun. 18, 2013
The United States of America As Represented BY the Secretary of the Department of Health and Human Services, Washington, DC (US);
Kimberly A. Dodd, Decatur, GA (US);
Brian H. Bird, Atlanta, GA (US);
Cesar G. Albarino, Atlanta, GA (US);
Stuart T. Nichol, Atlanta, GA (US);
Abstract
Disclosed herein is a robust system for the reverse genetics generation of a Rift Valley fever (RVF) virus replicon particle (VRP) vaccine candidate. VRPcan actively synthesize viral RNA and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity. Is it disclosed herein that VRPimmunization is both safe and efficacious, resulting in a robust immune response that is protective against RVF virus challenge within 24 hours of immunization. Provided herein are VRP, methods of producing VRP, and method of using VRPfor immunization against RVF virus infection.