The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2017
Filed:
Apr. 04, 2012
Applicants:
Bruce R. Zetter, Wayland, MA (US);
Amy Holleman, Woudenberg, NL;
Ivy Chung, Boston, MA (US);
Inventors:
Assignee:
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 31/337 (2006.01); A61K 45/06 (2006.01); A61K 31/7088 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/337 (2013.01); A61K 31/7088 (2013.01); A61K 45/06 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01);
Abstract
Provided herein are methods and assays relating to the diagnosis and treatment of a taxane-resistant cancer. Such methods and assays comprise determining the level of expression of miR-135in a biological sample from a subject having or suspected of having a taxane-resistant cancer or from a subject that was or is being treated with a taxane anti-cancer agent. Also provided herein are methods for treating such cancers by administering an inhibitor of the miR-135pathway and a taxane to a subject in need thereof.