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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9687466 B1

PDFFull Text
Date of Patent:
Jun. 27, 2017

Filed:

Apr. 04, 2014

Use of dianhydrogalactitol and analogs and derivatives thereof to treat glioblastoma multiforme

Applicant:

Delmar Pharmaceuticals, Inc., Vancouver, CA;

Inventors:

Jeffrey A. Bacha, Vancouver, CA;

Dennis Brown, Menlo Park, CA (US);

Sandra Dunn, Vancouver, CA;

Anne Steinø, Vancouver, CA;

Assignee:

DELMAR PHARMACEUTICALS, INC., Vancouver, CA;

Attorney:

Ditthavong & Steiner, P.C.

Primary Examiner:

Kevin E Weddington

Int. Cl.
CPC ...
A61K 31/045 (2006.01); A61K 31/336 (2006.01); C12Q 1/68 (2006.01); A61K 31/4188 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61K 31/495 (2006.01); A61K 31/047 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/336 (2013.01); A61K 31/047 (2013.01); A61K 31/4188 (2013.01); A61K 31/495 (2013.01); A61K 45/06 (2013.01); A61K 47/482 (2013.01); A61K 47/48038 (2013.01); A61K 47/48238 (2013.01); A61N 5/1007 (2013.01); C12Q 1/6886 (2013.01); A61N 5/10 (2013.01); A61N 2005/1024 (2013.01); A61N 2005/1098 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/154 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme. Dianhydrogalactitol acts as an alkylating agent on DNA that creates Nmethylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.

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Bacha, Jeffrey. (2017). Use of dianhydrogalactitol and analogs and derivatives thereof to treat glioblastoma multiforme (U.S. Patent No. 9687466). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9687466

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