The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

Aug. 24, 2015
Applicant:

Invista North America Sa.r.l., Wilmington, DE (US);

Inventors:

Eric Althoff, Seattle, WA (US);

Nadia Kadi, Marton, GB;

Mihai Luchian Azoitei, Chapel Hill, NC (US);

Yih-En A Ban, Seattle, WA (US);

Daniela Grabs-Röthlisberger, Seattle, WA (US);

Alexander Pisarchik, Bothell, WA (US);

Alexandre Zanghellini, Seattle, WA (US);

Adriana L. Botes, Rosedale East, GB;

Assignee:

INVISTA NORTH AMERICA S.A.R.L., Wilmington, DE (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); A61K 38/00 (2006.01); C12P 5/00 (2006.01); C12P 5/02 (2006.01); C07C 11/167 (2006.01); C07C 11/18 (2006.01); C07C 11/21 (2006.01); C07K 16/40 (2006.01); C08F 36/06 (2006.01); C08F 36/08 (2006.01); C08F 36/22 (2006.01); G01N 33/573 (2006.01); C08F 136/06 (2006.01); C08F 136/08 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); A61K 38/00 (2013.01); C07C 11/167 (2013.01); C07C 11/18 (2013.01); C07C 11/21 (2013.01); C07K 16/40 (2013.01); C08F 36/06 (2013.01); C08F 36/08 (2013.01); C08F 36/22 (2013.01); C08F 136/06 (2013.01); C08F 136/08 (2013.01); C12P 5/007 (2013.01); C12P 5/026 (2013.01); C12Y 402/01127 (2013.01); G01N 33/573 (2013.01); C07K 2299/00 (2013.01); C12Y 402/01053 (2013.01); C12Y 402/01095 (2013.01); C12Y 402/01131 (2013.01);
Abstract

The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.


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