logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9682998 B1

PDFFull Text
Date of Patent:
Jun. 20, 2017

Filed:

Jun. 21, 2016

Fused heterocyclic compounds as ion channel modulators

Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Britton Kenneth Corkey, Redwood City, CA (US);

Elfatih Elzein, Fremont, CA (US);

Michael Graupe, Pacifica, CA (US);

Juan Guerrero, Concord, CA (US);

Robert H. Jiang, Cupertino, CA (US);

Rao V. Kalla, Cupertino, CA (US);

Tetsuya Kobayashi, Pleasanton, CA (US);

Dmitry Koltun, Foster City, CA (US);

Xiaofen Li, Mountain View, CA (US);

Ruben Martinez, San Diego, CA (US);

Gregory Notte, San Mateo, CA (US);

Eric Q. Parkhill, San Francisco, CA (US);

Thao Perry, San Jose, CA (US);

Chandrasekar Venkataramani, Redwood City, CA (US);

Jeff Zablocki, Los Altos, CA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorney:

Francis O. Ginah

Primary Examiner:

Venkataraman Balasubramanian

Int. Cl.
CPC ...
C07D 255/04 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 403/08 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01); A61K 31/53 (2006.01); A61P 25/08 (2006.01); C07D 498/10 (2006.01); C07D 498/04 (2006.01); C07D 263/58 (2006.01); C07D 237/32 (2006.01); C07D 239/88 (2006.01); C07D 239/90 (2006.01); C07D 253/08 (2006.01); C07D 265/22 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01); C07D 217/26 (2006.01); C07D 413/12 (2006.01); C07D 279/08 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 498/10 (2013.01); C07D 217/26 (2013.01); C07D 237/32 (2013.01); C07D 239/88 (2013.01); C07D 239/90 (2013.01); C07D 253/08 (2013.01); C07D 263/58 (2013.01); C07D 265/22 (2013.01); C07D 279/08 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/08 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/06 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 498/04 (2013.01);
Abstract

The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R, X, X, Y and Rare as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Find Patent Forward Citations

Loading…