The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2017
Filed:
Jan. 28, 2014
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Lars Bärfacker, Düsseldorf, DE;
Stefan Prechtl, Berlin, DE;
Gerhard Siemeister, Berlin, DE;
Antje Margret Wengner, Berlin, DE;
Jens Ackerstaff, Düsseldorf, DE;
Katrin Nowak-Reppel, Berlin, DE;
Benjamin Bader, Berlin, DE;
Philip Lienau, Berlin, DE;
Detlef Stöckigt, Potsdam, DE;
Tobias Heinrich, Berlin, DE;
BAYER PHARMA AKTIENGESELLSCHAFT, Berlin, DE;
Abstract
The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint: in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.