The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

Dec. 31, 2010
Applicants:

Joaquín Pastor Fernández, Madrid, ES;

Francisco Javier Ramos Lima, Madrid, ES;

Ana Isabel Hernandez Higueras, Madrid, ES;

Sonia Martínez González, Madrid, ES;

Jose Ignacio Martín Hernando, Madrid, ES;

Carl-gustave Pierre Saluste, Madrid, ES;

Esther Gonzalez Cantalapiedra, Madrid, ES;

Carmen Blanco Aparicio, Madrid, ES;

Antonio Rodríguez Hergueta, Madrid, ES;

Ana Maria Garcia Collazo, Madrid, ES;

Antonio Salgado Serrano, Madrid, ES;

Beatriz Noya Marino, Madrid, ES;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/14 (2006.01); C07D 487/14 (2006.01);
U.S. Cl.
CPC ...
C07D 491/14 (2013.01); C07D 487/14 (2013.01);
Abstract

There is provided compounds of formula (I), wherein R, R, Rand Rhave meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).


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