The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

Dec. 09, 2014
Applicant:

Glenmark Pharmaceuticals S.a., La Chaux-de-Fonds, CH;

Inventors:

Sanjib Das, West Bengal, IN;

Sachin Sundarlal Chaudhari, Navi Mumbai, IN;

Abraham Thomas, Navi Mumbai, IN;

Shailesh Ramesh Pardeshi, Maharashtra, IN;

Vishal Govindrao Deshmukh, Maharashtra, IN;

Prashant Dilip Wadekar, Maharashtra, IN;

Neelima Khairatkar-Joshi, Thane, IN;

Daisy Manish Shah, Mumbai, IN;

Malini Bajpai, Uttar Pradesh, IN;

Assignee:

GLENMARK PHARMACEUTICALS S.A., La Chaux-de-Fonds, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 209/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 209/12 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01);
Abstract

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X, M, R, R, R, R, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.


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