The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

Dec. 31, 2013
Applicant:

Estryx Pharma Limited, Combe, Witney, Oxfordshire, GB;

Inventors:

Serge Auvin, Palaiseau, FR;

Olivier Lavergne, Palaiseau, FR;

Qi Chao, San Diego, CA (US);

Yufeng Chen, Zhejiang, CN;

Assignee:

ESTRYX PHARMA LIMITED, Combe, Witney, Oxfordshire, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 235/16 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/4192 (2006.01); A61K 31/444 (2006.01); C07D 249/18 (2006.01); C07D 235/06 (2006.01); C07D 401/06 (2006.01); C07D 235/22 (2006.01); C07D 403/06 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 235/16 (2013.01); A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/4192 (2013.01); A61K 31/444 (2013.01); C07D 235/06 (2013.01); C07D 235/22 (2013.01); C07D 249/18 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to new biphenyl derivatives of formula These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.


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