The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2017
Filed:
Sep. 02, 2014
Centre National DE LA Recherche Scientifique-cnrs, Paris Cedex, FR;
Universite DE Reims Champagne-ardenne, Reims Cedex, FR;
Samir Bouzbouz, Saint Etienne du Rouvray, FR;
Xavier Pannecoucke, Maromme, FR;
Azzaq Belaaouaj, Muizon, FR;
Laurette Malleret, Reims, FR;
Clement Denhez, Reims, FR;
Dominique Guillaume, Ville en Selve, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Paris, FR;
UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, Reims, FR;
Abstract
The invention relates to new α-vinyl carbonylated compounds corresponding to general formula (I), wherein R, R,R, R, Rand Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compound (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.