IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9682928 B1

PDFFull Text
Date of Patent:
Jun. 20, 2017

Filed:

Aug. 28, 2014

Bumetanide analogs, compositions and methods of use

Applicant:

Neuropro Therapeutics, Inc., Bahama, NC (US);

Inventors:

John J. Partridge, Chapel Hill, NC (US);

Daryl W. Hochman, Bahama, NC (US);

Assignee:

NeuroPro Therapeutics, Inc., Bahama, NC (US);

Attorney:

Brinks Gilson & Lione

Primary Examiner:

Rebecca Anderson

Int. Cl.
CPC ...
C07D 295/084 (2006.01); C07C 311/39 (2006.01); A61K 31/4355 (2006.01); C07D 211/44 (2006.01); C07D 231/04 (2006.01); C07D 233/02 (2006.01); C07D 237/02 (2006.01); C07D 239/04 (2006.01); C07D 241/04 (2006.01); C07D 261/02 (2006.01); C07D 263/04 (2006.01); C07D 265/30 (2006.01); C07D 275/02 (2006.01); C07D 277/04 (2006.01); C07D 279/12 (2006.01); C07D 307/52 (2006.01);
U.S. Cl.
CPC ...
C07C 311/39 (2013.01); A61K 31/4355 (2013.01); C07D 211/44 (2013.01); C07D 231/04 (2013.01); C07D 233/02 (2013.01); C07D 237/02 (2013.01); C07D 239/04 (2013.01); C07D 241/04 (2013.01); C07D 261/02 (2013.01); C07D 263/04 (2013.01); C07D 265/30 (2013.01); C07D 275/02 (2013.01); C07D 277/04 (2013.01); C07D 279/12 (2013.01); C07D 295/084 (2013.01); C07D 307/52 (2013.01);
Abstract

The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the NaKClco-transporter or GABAreceptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma. Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

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