The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2017
Filed:
Aug. 05, 2013
Applicant:
Bmi Korea Co., Ltd, Jeju, KR;
Inventors:
Assignee:
BMI KOREA CO., LTD, Jeju-si, KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/26 (2006.01); A61K 47/34 (2017.01); A61K 38/47 (2006.01); C12N 9/96 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/18 (2017.01);
U.S. Cl.
CPC ...
A61K 47/34 (2013.01); A61K 9/0019 (2013.01); A61K 38/47 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); C12N 9/2408 (2013.01); C12N 9/2474 (2013.01); C12N 9/96 (2013.01); C12Y 302/01035 (2013.01);
Abstract
This invention relates to a stable hyaluronidase liquid formulation comprising a hyaluronidase and a stabilizer for hyaluronidase. In particular, the hyaluronidase has a purity of 95% or more and the specific activity of 70,000 IU/mg or more, and the stabilizer for hyaluronidase contains a buffering agent in order to provide pH of 4.0 to 6.0; 0.001 to 0.5 v/v % of a non-ionic surfactant; and 0.1 to 5 mM of a chelating agent or MgCl. The liquid formulation has advantages in that it stably maintains its activity for a long period of time and may be easily administered than the conventional formulations.