The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

Dec. 22, 2014
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Rudolph L. Leibel, New York, NY (US);

Kazuhisa Watanabe, Shimotsuke, JP;

Wendy K. Chung, Hackensack, NJ (US);

Stuart G. Fischer, New Rochelle, NY (US);

Charles Leduc, Hackensack, NJ (US);

Elizabeth Watson, New York, NY (US);

Maria Laura Cremona, Englewood, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/17 (2006.01); A61K 31/00 (2006.01); C07K 14/705 (2006.01); A01K 67/027 (2006.01); A61K 45/06 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A01K 67/0276 (2013.01); A61K 31/00 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); C07K 14/70503 (2013.01); A01K 2217/075 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0362 (2013.01); A61K 48/00 (2013.01);
Abstract

The invention provides methods for treating metabolic disease in a subject and methods for increasing the expression of ILDR2 in a subject. The invention further provides a method for identifying an agent which modulates expression of an Ildr2 RNA comprising contacting a cell with an agent; determining expression of the Ildr2 RNA in the presence and the absence of the agent; and comparing expression of the Ildr2 RNA in the presence and the absence of the agent, wherein a change in the expression of the Ildr2 RNA in the presence of the agent is indicative of an agent which modulates the level of expression of the RNA.


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