The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2017
Filed:
Mar. 11, 2014
Applicant:
Shifa Biomedical Corporation, Malvern, PA (US);
Inventors:
Sherin Salaheldin Abdel-Meguid, Exton, PA (US);
Nabil Elshourbagy, Chester, PA (US);
Harold Meyers, Weston, PA (US);
Shaker A. Mousa, Wynantskill, NY (US);
Assignee:
Shifa Biomedical Corporation, Malvern, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/4015 (2006.01); A61K 31/4439 (2006.01); A61K 31/433 (2006.01); A61K 31/42 (2006.01); A61K 31/4196 (2006.01); A61K 31/426 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/415 (2006.01); A61K 31/4545 (2006.01); A61K 31/4178 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/404 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/426 (2013.01); A61K 31/433 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/4015 (2013.01);
Abstract
Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia. Examples of compounds include thiadiazole, isoxazole, 1,2,4-triazole, thiazole, indole, pyrazole, and pyrrolinone derivatives.