The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

May. 07, 2014
Applicant:

Nerviano Medical Sciences S.r.l., Nerviano, IT;

Inventors:

Mauro Angiolini, Gavirate, IT;

Laura Buffa, Rossiglione, IT;

Maria Menichincheri, Milan, IT;

Ilaria Motto, Nerviano, IT;

Paolo Polucci, Cassina Rizzardi, IT;

Gabriella Traquandi, Milan, IT;

Fabio Zuccotto, Milan, IT;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 31/496 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.


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