The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2017
Filed:
Feb. 03, 2014
Bioversys Ag, Basel, CH;
Peter Schneider, Bottmingen, CH;
Rainer Riedl, Wilen bei Wollerau, CH;
Marcel Tigges, Reinach, CH;
Marc Gitzinger, Eiken, CH;
Michel Pieren, Binningen, CH;
Assaf Levi, Basel, CH;
Mark Sephton, Cambridge, GB;
Birgit Schellhorn, Well am Rhen, DE;
Patrik Zueger, Adliswil, CH;
Michael Brand, Staufen, CH;
Daniel Gygax, Himmelried, CH;
Peter Spies, Zwingen, CH;
BIOVERSYS AG, , CH;
Abstract
The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens.