The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

Oct. 31, 2013
Applicants:

Pathogen Removal and Diagnostic Technologies, Inc., Wilmington, DE (US);

North Carolina State University, Raleigh, NC (US);

Inventors:

David J. Hammond, Laytonsville, MD (US);

Julia T. Lathrop, Falls Church, VA (US);

Larisa Cervenakova, Rockville, MD (US);

Ruben G. Carbonell, Raleigh, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C07K 5/083 (2006.01); C07K 5/087 (2006.01); C07K 5/093 (2006.01); C07K 5/097 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); C07K 5/081 (2013.01); C07K 5/0808 (2013.01); C07K 5/0812 (2013.01); C07K 5/0819 (2013.01); C07K 5/0821 (2013.01); C07K 14/47 (2013.01); G01N 2800/2828 (2013.01);
Abstract

Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.


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